Knee extensor strength gains mediate symptom improvement in knee osteoarthritis: secondary analysis of a randomised controlled trial

M Hall; RS Hinman; TV Wrigley; J Kasza; BW Lim; KL Bennell

Journal article

Knee extensor strength gains mediate symptom improvement in knee osteoarthritis: secondary analysis of a randomised controlled trial

M Hall, RS Hinman, TV Wrigley, J Kasza, BW Lim, KL Bennell

Osteoarthritis and Cartilage | Published : 2018

DOI: 10.1016/j.joca.2018.01.018

Abstract

Objective: To determine if an increase in knee extensor strength mediates the effect of a 12-week knee extensor strength training program on pain and physical function improvement in people with knee osteoarthritis (OA). Design: Secondary analysis from a randomised controlled trial comparing the effects of a 12-week knee extensor strengthening exercise program to a control group with no intervention. Methods: Data from participants with complete data (n = 97) enrolled in a previous clinical trial were analysed. Baseline and 12-week follow-up assessments included peak isometric knee extensor strength, pain and physical function. Peak knee extensor strength (Nm/kg) was assessed on an isokineti..

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University of Melbourne Researchers

Michelle Hall Author

Rana Hinman Author

Kim Bennell Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

MH is supported by a Sir Randal Heymanson Research Fellowship from the University of Melbourne. RSH is supported by a Future Fellowship from the Australian Research Council (FT130100175). KLB is supported by a NHMRC Principal Research Fellowship (APP1058440). The study sponsors did not play any role in the study design, collection, analysis or interpretation of data, writing of the manuscript, decision to submit the manuscript for publication.